Are Uterine Fibroids Genetic?

Understanding the Role of Genetics in Uterine Fibroid Development

While the exact cause of fibroids remains unclear, there is significant evidence suggesting a genetic predisposition plays a key role in their development.  Recent advancements in genetic research have identified specific gene variants and pathways that may contribute to fibroid development. Studies have focused on understanding how these genetic factors interact with environmental and hormonal influences to affect fibroid growth and progression. Genetic studies offer valuable insights into potential targeted therapies and personalized treatment approaches for individuals affected by fibroids.

Are Fibroids Genetic?

Possibly. Evidence suggests that women who have one or more close relatives with fibroids — particularly their mother or sisters — are more likely to develop them themselves.

While uterine fibroids are influenced by a combination of genetic, hormonal, and environmental factors, genetics plays a significant role in predisposing individuals to develop these common tumors. Understanding the genetic basis of fibroids is crucial for early detection, personalized treatment approaches, and empowering individuals to take proactive steps towards managing their health. Continued research into genetic factors promises to further enhance our understanding and improve outcomes for individuals affected by uterine fibroids.

Will I Get Fibroids if My Mom Had Them?

While genetics seem to play a role in uterine fibroids, they’re certainly not the only factor — or even the main factor — in determining your chances of getting them. So, if your sister or mom has fibroids, it doesn’t necessarily mean you’ll have them too. However, you will be at an increased risk.

If you’re worried that you might have fibroids, talk to your doctor or one of the specialists at our center. We’ll be happy to help you determine your likelihood of having fibroids and find the best treatment option for your needs.

What Causes Uterine Fibroids to Form?

Thirty-three percent of women develop fibroids in their 20s to 30s, and genetics is just one of many potential factors. While their exact causes are still unknown, studies point to the following as a couple of other potential determinants of fibroids:

  • Hormones: Progesterone and estrogen — hormones that stimulate the uterine lining’s growth each month during the menstrual cycle — seem to be a primary factor in fibroid growth. Fibroids tend to grow when hormone levels are at their highest during a woman’s childbearing years — particularly during pregnancy. When these hormones slow their production during menopause, fibroid growth typically stops.
  • Changes in genes: Researchers have found that fibroids often have genetic changes different from normal uterine cells. Researchers at Brigham and Women’s Hospital (BWH) discovered a genetic risk allele (which is an alternative form of a gene) for fibroids in women of Caucasian descent. More studies need to occur to secure additional data for women of various ages and racial groups.

Along with these causes, research has found a few known factors related to fibroid development. You have a greater risk of developing fibroids if you:

  • Have a family history of uterine fibroids
  • Are of African-American descent
  • Have a high Body Mass Index (BMI)
  • Frequently eat red meat and don’t often eat fruits or vegetables
  • Regularly drink alcohol or caffeine, not enough water
  • Have a Vitamin D deficiency
  • Began menstruating at an early age

If you fall into one of the categories above, it’s important to track your menstrual symptoms and tell your doctor if anything changes. If you are experiencing heavy, painful periods or other symptoms listed on our uterine fibroid symptoms guide, then you may want to talk to a physician who specializes in uterine fibroids. A fibroid specialist will be able to look at your family and medical history to determine if genetics play a role in your fibroid development.

Contact USA Fibroid Centers

Even if uterine fibroids are genetic, you have the ability to choose your next steps. No one should be forced to live with the chronic pain that often comes with having fibroids. If you or a loved one are looking for lasting relief from fibroid symptoms, USA Fibroid Centers can help.

For more information about fibroids or to learn more about diagnosis and treatment, reach out to today by calling us at 855.615.2555 or clicking the button below. Our fibroid specialists are here to answer any questions you might have and guide you toward the treatment plan that’s right for you.

Talk to a Fibroid Specialist Today